Citation: Ming Ming Yan, Ting You Li, Da Qing Zhao, Shuai Shao, Sheng Nan Bi. A new derivative of triterpene with anti-melanoma B16 activity from Conyza canadensis[J]. Chinese Chemical Letters, ;2010, 21(7): 834-837. doi: 10.1016/j.cclet.2010.02.022 shu

A new derivative of triterpene with anti-melanoma B16 activity from Conyza canadensis

a Changchun University of Chinese Medicine, Changchun 130117, China;
b School of Pharmacy, Nanjing Medical University, Nanjing 210029, China

Received Date: 12 November 2009

A new derivative of triterpene named Erigeronol 1 was isolated from the EtOH extract of the aerial part of Conyza canadensis together with 15 known compounds for the first time from this plant.The structure of Erigeronol 1 was elucidated as 3-O-(hydroxyacetyl)-23,28-dihydroxy-β-amyrin by hydrolysis and spectroscopic analysis.Erigeronol 1 showed potent cytotoxic activity with IC₅₀ value of 7.77±0.47 μg/mL against melanoma B16 determined by the 3-(4,5-dimethylthiazo-2-yl)-2,5-dipbenyltetrazolium bromide(MTT)method.
- Conyza canadensis,
- Derivative of triterpene,
- Anti-melanoma B16
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