Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers (I):Tethered with a fused heterocyclic s-triazolo [2,1-b] [1,3,4]thiadiazole

Guo Qiang Hu Zhong Quan Zhang Song Qiang Xie Wen Long Huang

引用本文: Guo Qiang Hu,  Zhong Quan Zhang,  Song Qiang Xie,  Wen Long Huang. Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers (I):Tethered with a fused heterocyclic s-triazolo [2,1-b] [1,3,4]thiadiazole[J]. Chinese Chemical Letters, 2010, 21(6): 661-663. doi: 10.1016/j.cclet.2010.01.037 shu
Citation:  Guo Qiang Hu,  Zhong Quan Zhang,  Song Qiang Xie,  Wen Long Huang. Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers (I):Tethered with a fused heterocyclic s-triazolo [2,1-b] [1,3,4]thiadiazole[J]. Chinese Chemical Letters, 2010, 21(6): 661-663. doi: 10.1016/j.cclet.2010.01.037 shu

Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers (I):Tethered with a fused heterocyclic s-triazolo [2,1-b] [1,3,4]thiadiazole

  • 基金项目:

    This project was supported by National Natural Science Foundation of China (No. 20872028).

摘要: Five C3/C3 fluoroquinolone dimers tethered with a fused heterocyclic ring of s-triazolo[2,1-b] [1,3,4]thiadiazole derived from antibacterial quinolones were synthesized and characterized, and their in vitro antitumor activity against L1210, CHO cell lines was evaluated via the respective IC50 values.

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  • 收稿日期:  2009-09-08
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