Citation: Gen Yan Liu, Wei Miao, Xiu Lian Ju. Mechanisms of imidacloprid resistance in Nilaparvata lugens by molecular modeling[J]. Chinese Chemical Letters, ;2010, 21(4): 492-495. doi: 10.1016/j.cclet.2009.12.017 shu

Mechanisms of imidacloprid resistance in Nilaparvata lugens by molecular modeling

Gen Yan Liu ^a,b, ,
Wei Miao ^a ,
Xiu Lian Ju ^a,b

a Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430073, China;
b Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, The Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received Date: 17 August 2009

Homology models of the ligand binding domain of the wild-type and Y151S mutant brown planthopper(Nilaparvata lugens)α1and rat(Rattus norvegicus)β2 nicotinic acetylcholine receptor(nAChR)subunits were generated based on the crystal structure of acetylcholine binding protein of Lymnaea stagnalis.Neonicotinoid insecticide imidacloprid was docked into the putative binding site of wild-type and mutant α1β2 dimeric receptors by Surflex-docking,and the calculated docking energies were in agreement with experimental results.The resistance mechanisms and corresponding binding modes of imidacloprid on nAChRs containing the Y151S target-site mutation were discussed.
- nAChR,
- Imidaeloprid,
- Homology model,
- Docking,
- Resistance
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