Citation: Yuan Yuan Zhang, Xing Yan Zeng, Kui Nie, Zhi Cheng Zhong, Yu Liang Wang, Yu Zhong Wang. Synthesis and biological evaluation of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates against Eimeria tenella[J]. Chinese Chemical Letters, ;2010, 21(4): 426-428. doi: 10.1016/j.cclet.2009.12.006 shu

Synthesis and biological evaluation of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates against Eimeria tenella

a Department of Chemical Engineering, Sichuan University, Chengdu 610065, China;
b College of Animal Science and Technology, Southwest University, Chongqing 400715, China;
c Department of Chemistry, Sichuan University, Chengdu 610064, China

Received Date: 24 August 2009

Fund Project: We appreciate the financial support from the National Science Foundation of China (No. 20372052) and NMR analysis by Sichuan University Analytical & Testing Center.

A series of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates were designed and synthesized.Their structures were confirmed by ¹H NMR,¹³C NMR,IR and HRMS.The biological activities were primarily evaluated against Eimeria tenella according to Anticoccidial Index(ACI)method in vivo.The results showed that compounds 5e,5f and 5i exhibited anticoccidial activities against E.tenella at 27 mg kg^-1.
- Ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylate,
- Synthesis,
- Anticoccidial activity,
- Eimeria tenella
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