Citation: Ratnadeep S. Joshi, Priyanka G. Mandhane, Mohammad U. Shaikh, Rajesh P. Kale, Charansingh H. Gill. Potassium dihydrogen phosphate catalyzed one-pot synthesis of 2,4,5-triaryl-1H-imidazoles[J]. Chinese Chemical Letters, ;2010, 21(4): 429-432. doi: 10.1016/j.cclet.2009.11.012 shu

Potassium dihydrogen phosphate catalyzed one-pot synthesis of 2,4,5-triaryl-1H-imidazoles

Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra 431 004, India

Received Date: 26 August 2009

Fund Project: The authors are thankful to University Grants Commission, New Delhi, for financial support and to the Head, Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, for his valuable support and laboratory facilities.

A simple and efficient method has been developed; benzil/benzoin undergoes smooth condensation with various substituted aldehyde and ammonium acetate in the presence of potassium dihydrogen phosphate(KH₂PO₄)under mild reaction conditions to afford the corresponding trisubstituted imidazole in excellent yields.The method for synthesis of product,the reaction mixture was reflux in ethanol for 40-90 min.The present method is simple,efficient,and cost-effective.
- Potassium dihydrogen phosphate(KH₂PO₄),
- 2,4,5-Triaryl-1H-imidazole,
- Benzil,
- Benzoin,
- Aldehyde,
- Ammonium acetate
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