引用本文:
Yi Kai Zhang, Zhi Liang Lv, Chun Juan Niu, Ke Li. Synthesis and anti-HBV activity of novel 5-substituted pyridin-2(1H)-one derivatives[J]. Chinese Chemical Letters,
2010, 21(3): 290-292.
doi:
10.1016/j.cclet.2009.10.010
Citation: Yi Kai Zhang, Zhi Liang Lv, Chun Juan Niu, Ke Li. Synthesis and anti-HBV activity of novel 5-substituted pyridin-2(1H)-one derivatives[J]. Chinese Chemical Letters, 2010, 21(3): 290-292. doi: 10.1016/j.cclet.2009.10.010
Citation: Yi Kai Zhang, Zhi Liang Lv, Chun Juan Niu, Ke Li. Synthesis and anti-HBV activity of novel 5-substituted pyridin-2(1H)-one derivatives[J]. Chinese Chemical Letters, 2010, 21(3): 290-292. doi: 10.1016/j.cclet.2009.10.010
Synthesis and anti-HBV activity of novel 5-substituted pyridin-2(1H)-one derivatives
摘要:
Four novel 5-substituted pyridine-2(1H)-one derivatives were designed and synthesized by using addition-elimination reactions. The structures of these novelly synthesized compounds were verified by 1H NMR, ESI-MS and single crystal X-ray diffraction. Furthermore, all four compounds (most notably compound 7a) were found to be highly efficient against hepatitis B virus (HBV) in cultured HepG22.2.15 cell, making them promising drug candidates for potential bioactive molecule against hepatitis B.
English
Synthesis and anti-HBV activity of novel 5-substituted pyridin-2(1H)-one derivatives
Abstract:
Four novel 5-substituted pyridine-2(1H)-one derivatives were designed and synthesized by using addition-elimination reactions. The structures of these novelly synthesized compounds were verified by 1H NMR, ESI-MS and single crystal X-ray diffraction. Furthermore, all four compounds (most notably compound 7a) were found to be highly efficient against hepatitis B virus (HBV) in cultured HepG22.2.15 cell, making them promising drug candidates for potential bioactive molecule against hepatitis B.
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Key words:
- Substituted pyridin-2(1H)-one
- / Synthesis
- / Crystal structure
- / Anti-HBV activity
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