引用本文:
Yun Mei Bi, Xiao Ying Gong, Wen Zhao Wang, Li Yub, Min Qi Hu, Li Dong Shao. Synthesis and characterization of new biodegradable thermosensitive polyphosphazenes with lactic acid ester and methoxyethoxyethoxy side groups[J]. Chinese Chemical Letters,
2010, 21(2): 237-241.
doi:
10.1016/j.cclet.2009.10.003
Citation: Yun Mei Bi, Xiao Ying Gong, Wen Zhao Wang, Li Yub, Min Qi Hu, Li Dong Shao. Synthesis and characterization of new biodegradable thermosensitive polyphosphazenes with lactic acid ester and methoxyethoxyethoxy side groups[J]. Chinese Chemical Letters, 2010, 21(2): 237-241. doi: 10.1016/j.cclet.2009.10.003

Citation: Yun Mei Bi, Xiao Ying Gong, Wen Zhao Wang, Li Yub, Min Qi Hu, Li Dong Shao. Synthesis and characterization of new biodegradable thermosensitive polyphosphazenes with lactic acid ester and methoxyethoxyethoxy side groups[J]. Chinese Chemical Letters, 2010, 21(2): 237-241. doi: 10.1016/j.cclet.2009.10.003

Synthesis and characterization of new biodegradable thermosensitive polyphosphazenes with lactic acid ester and methoxyethoxyethoxy side groups
摘要:
Two novel biodegradable thermosensitive polyphosphazenes with lactic acid ester and methoxyethoxyethoxy side groups were synthesized via the macromolecular substitution reactions of poly(dichlorophosphazene)with the sodium salt of lactic acid ester and sodium methoxyethoxyethoxide.Their structures were confirmed by 31p NMR,1H NMR,13C NMR,IR,DSC,and elemental analysis.The lower critical solution temperature(LCST)behavior in water and in vitro degradation property of the polymers was investigated.The results indicated that two polymers showed LCST phase transition over a range of concentrations from 0.13 to 15 wt% and pH-sensitive degradation properties.
English
Synthesis and characterization of new biodegradable thermosensitive polyphosphazenes with lactic acid ester and methoxyethoxyethoxy side groups
Abstract:
Two novel biodegradable thermosensitive polyphosphazenes with lactic acid ester and methoxyethoxyethoxy side groups were synthesized via the macromolecular substitution reactions of poly(dichlorophosphazene)with the sodium salt of lactic acid ester and sodium methoxyethoxyethoxide.Their structures were confirmed by 31p NMR,1H NMR,13C NMR,IR,DSC,and elemental analysis.The lower critical solution temperature(LCST)behavior in water and in vitro degradation property of the polymers was investigated.The results indicated that two polymers showed LCST phase transition over a range of concentrations from 0.13 to 15 wt% and pH-sensitive degradation properties.
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Key words:
- Polyphosphazene
- / Lactic acid ester
- / Methoxyethoxyethoxy
- / Biodegradation
- / Thermosensitive polymer

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