Citation: Yun Mei Bi, Xiao Ying Gong, Wen Zhao Wang, Li Yub, Min Qi Hu, Li Dong Shao. Synthesis and characterization of new biodegradable thermosensitive polyphosphazenes with lactic acid ester and methoxyethoxyethoxy side groups[J]. Chinese Chemical Letters, ;2010, 21(2): 237-241. doi: 10.1016/j.cclet.2009.10.003 shu

Synthesis and characterization of new biodegradable thermosensitive polyphosphazenes with lactic acid ester and methoxyethoxyethoxy side groups

a College of Chemistry and Engineering, Yunnan Normal University, Kunming 650092, China;
b College of Chemistry and Chemical Engineering, Chonqing College of Science and Technology, Chongqing 40042, China

Received Date: 10 June 2009

Fund Project: The authors gratefully acknowledge support for this work of the National Natural Foundation of China (No. 20364002) and the Natural Science Foundation of Yunnan Province (No. 2005B0027 M), China.

Two novel biodegradable thermosensitive polyphosphazenes with lactic acid ester and methoxyethoxyethoxy side groups were synthesized via the macromolecular substitution reactions of poly(dichlorophosphazene)with the sodium salt of lactic acid ester and sodium methoxyethoxyethoxide.Their structures were confirmed by ³¹p NMR,¹H NMR,¹³C NMR,IR,DSC,and elemental analysis.The lower critical solution temperature(LCST)behavior in water and in vitro degradation property of the polymers was investigated.The results indicated that two polymers showed LCST phase transition over a range of concentrations from 0.13 to 15 wt% and pH-sensitive degradation properties.
- Polyphosphazene,
- Lactic acid ester,
- Methoxyethoxyethoxy,
- Biodegradation,
- Thermosensitive polymer
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