Citation: Shuai Jian Ni, Hui Bin Zhang, Wen Long Huang, Jin Pei Zhou, Hai Qian. Solid phase synthesis of fatty acid modified glucagon-like peptide-1 (7-36) amide under thermal and controlled microwave irradiation[J]. Chinese Chemical Letters, ;2010, 21(1): 27-30. doi: 10.1016/j.cclet.2009.08.007 shu

Solid phase synthesis of fatty acid modified glucagon-like peptide-1 (7-36) amide under thermal and controlled microwave irradiation

Center for Drug Discovery, China Pharmaceutical University, Nanjing 210009, China

Received Date: 17 May 2009

Fund Project: This work is financially supported by the Key Project of Chinese Ministry of Education (No. 109086) and the Graduate Students' Scientific Research Program of Jiangsu province.

Fatty acid modified glucagon-like peptide-1(7-36) amide was synthesized efficiently on Rink-Amide-MBHA resin by microwave-assisted solid phase method. The method of thermal and controlled microwave irradiation provided impressive enhancements in product yield, selectivity, and reaction rate. The coupling time was dramatically decreased to 6 min, and the desired products were obtained in high yield and purity.
- Glucagon-like peptide-1,
- GLP-1,
- Microwave,
- Solid phase,
- Fatty acid modification
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