Citation: Ju Xian Wang, Qiang Guo, Yun Chai, Lian Shun Feng, Hui Yuan Guo, Ming Liang Liu. Synthesis and in vitro antibacterial activities of 7-(4-alkoxyimino-3-hydroxypiperidin-l-yl)quinolone derivatives[J]. Chinese Chemical Letters, ;2010, 21(1): 55-58. doi: 10.1016/j.cclet.2009.07.011 shu

Synthesis and in vitro antibacterial activities of 7-(4-alkoxyimino-3-hydroxypiperidin-l-yl)quinolone derivatives

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Received Date: 4 June 2009

Fund Project: This work was supported by the IMB Research Foundation (No. IMBF 20060404).

A series of novel 7-(4-alkoxyimino-3-hydroxypiperidin-l-yl)quinolone derivatives were designed, synthesized and evaluated for in vitro antibacterial activities. Compounds 8f, 8g, 8i and 8j with the potencies similar to or better than those of levofloxacin and IMB against Staphylococcus aureus and Staphylococcus epidermidis, worth further investigation.
- Fluoroquinolone,
- Synthesis,
- Antibacterial activities
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