Citation: Jian Feng Xu, Peng Bin Li, Lu Ling Wu, Xian Huang. Regio- and stereo-selective synthesis of multi-substituted 3-pyrrolines[J]. Chinese Chemical Letters, ;2009, 20(9): 1015-1016. doi: 10.1016/j.cclet.2009.04.037 shu

Regio- and stereo-selective synthesis of multi-substituted 3-pyrrolines

a Department of Chemistry, Zhejiang University (Campus Xixi), Hangzhou 310028, China;
b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Received Date: 24 December 2008

Fund Project: We are grateful to the National Natural Science Foundation of China (No.20672095) and CAS Academician Foundation of Zhejiang Province for financial support.

A regio- and stereo-selective synthesis of multi-substituted 3-pyrrolines has been developed. The multi-substituted 3-pyrrolines were synthesized in good yields by 1,3-dipolar cycloaddition of methyl 2-(phenylselanyl)acrylate with azomethine ylides, followed by N-acylation and oxidation-elimination of phenylseleno group.
- 3-Pyrrolines,
- 1,3-Dipolar cycloaddition,
- Regioselective,
- Stereoselective
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