Citation: Xue Sen Fan Xia Wang, Xin Ying Zhang, Dong Feng, Ying Ying Qu. Preparation of nucleoside-pyridine hybrids and pyridine attached acylureas from an unexpected uracil ring-opening and pyridine ring-forming sequence[J]. Chinese Chemical Letters, ;2009, 20(10): 1161-1165. doi: 10.1016/j.cclet.2009.04.014 shu

Preparation of nucleoside-pyridine hybrids and pyridine attached acylureas from an unexpected uracil ring-opening and pyridine ring-forming sequence

School of Chemistry and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang 453007, China

Received Date: 11 February 2009

Fund Project: We are grateful to the National Natural Science Foundation of China (No.20772025)the Program for Science & Technology Innovation Talents in Universities of Henan Province (No.2008HASTIT006) and the Natural Science Foundation of Department of Education of Henan Province (No.2008A150013).Ref

Novel pyrimidine nucleoside-3,5-dicyanopyridine hybrids (4) or pyridine attached acylureas (5) were selectively and efficiently prepared from the reaction of 2'-deoxyuridin-5-yl-methylene malononitrile (1), malononitrile (2) and thiophenol (3) or from an unexpected uracil ring-opening and pyridine ring-forming sequence via the reaction of 1 and 3.It is the first time such a sequence has ever been reported.
- Pyrimidine nucleoside,
- Pyridine,
- Acylureas,
- Ring-opening and -forming reaction
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