Citation: Zai Gang Luo, Cheng Chu Zeng, Lei Fu Yang, Hong Qiu He, Cun Xin Wang, Li Ming Hu. Synthesis of 6-sulfamoyl-4-oxoquinoline-3-carboxylic acid derivatives as integrase antagonists with anti-HIV activity[J]. Chinese Chemical Letters, ;2009, 20(7): 789-792. doi: 10.1016/j.cclet.2009.03.014 shu

Synthesis of 6-sulfamoyl-4-oxoquinoline-3-carboxylic acid derivatives as integrase antagonists with anti-HIV activity

College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China

Received Date: 17 November 2008

Fund Project: The authors gratefully thank the financial supports of the National Basic Research Program (No.2009CB930200) and the Fund from Beijing City Education Committee (No.KM200610005029) and Funding Project for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality.

A series of novel 6-sulfamoyl-4-oxoquinoline-3-carboxylic acids derivatives have been synthesized and screened for HIV integrase inhibition activity. Their structures were confirmed by ESI-MS,¹H NMR and ¹³C NMR.
- Quinoline,
- Integrase,
- Anti-HIV-1 activity
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