Citation: Yu Lang Chi, Hui Ye Zhang, Jing Hua Xue, Jing Hao, Mei Fang Liu, Xiao Yi Wei. N²-(1-Methoxycarbonylethyl) guanosine, a new nucleoside coupled with an amino acid derivative from Amanita exitialis[J]. Chinese Chemical Letters, ;2009, 20(7): 830-832. doi: 10.1016/j.cclet.2009.02.008 shu

N²-(1-Methoxycarbonylethyl) guanosine, a new nucleoside coupled with an amino acid derivative from Amanita exitialis

a South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;
b Graduate School of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 27 November 2008

Fund Project: We thank Prof. Ruiqiang Chen,Guangzhou Institute of Chemistry,Chinese Academy of Sciences (CAS),for recording NMR spectra and Dr. Dongmei Fang,Chengdu Institute of Biology,CAS,for recording HRESIMS. This work was supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (No.KSCX2-YW-N-036).

A new purine nucleoside coupled with an amino acid derivative, N²-(1-methoxycarbonylethyl) guanosine 1, along with β-carbolineand russulaceramide was isolated from the fruiting bodies of Amanita exitialis, a newly described poisonous mushroom.Its structure was elucidated by spectroscopic methods. This is the first report of naturally occurring nucleosides in which an α-amino acid derivative is bonded through its α-amino nitrogen to a nucleobase aglycone by a C-N bond. The new compound was found to be toxic in brine shrimp lethality test (BST).
- N²-(1-Methoxycarbonylethyl)guanosine,
- Guanosine,
- Purine alkaloid,
- Nucleoside,
- Amanita,
- Amanita exitialis
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