引用本文:
Yong Qing Gao, Ning Zhou, Yu Jian Lv, Mao Shen Cheng, Ke Liang Liu. Ureido-modification of the resin-bound LHRH analogue with N,N'-carbonyldiimidazole[J]. Chinese Chemical Letters,
2009, 20(6): 668-671.
doi:
10.1016/j.cclet.2009.01.010
Citation: Yong Qing Gao, Ning Zhou, Yu Jian Lv, Mao Shen Cheng, Ke Liang Liu. Ureido-modification of the resin-bound LHRH analogue with N,N'-carbonyldiimidazole[J]. Chinese Chemical Letters, 2009, 20(6): 668-671. doi: 10.1016/j.cclet.2009.01.010
Citation: Yong Qing Gao, Ning Zhou, Yu Jian Lv, Mao Shen Cheng, Ke Liang Liu. Ureido-modification of the resin-bound LHRH analogue with N,N'-carbonyldiimidazole[J]. Chinese Chemical Letters, 2009, 20(6): 668-671. doi: 10.1016/j.cclet.2009.01.010
Ureido-modification of the resin-bound LHRH analogue with N,N'-carbonyldiimidazole
摘要:
The ureido-modification of the resin-bound a luteinizing hormone releasing hormone(LHRH) analogue was investigated by CDI-activating method.The amino group at the side chain of LHRH analogue could be transformed into various substituted urea moieties in high yields. However,is its teminal amino group was partially converted to a hydantoin stucture due to the Natom of the adjacent amide bond.
English
Ureido-modification of the resin-bound LHRH analogue with N,N'-carbonyldiimidazole
Abstract:
The ureido-modification of the resin-bound a luteinizing hormone releasing hormone(LHRH) analogue was investigated by CDI-activating method.The amino group at the side chain of LHRH analogue could be transformed into various substituted urea moieties in high yields. However,is its teminal amino group was partially converted to a hydantoin stucture due to the Natom of the adjacent amide bond.
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Key words:
- Urea moiety
- / N,N'-carbonyldiimidazole(CDI)
- / Solid-phase
- / peptide
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