Citation: Ping Zhang, Lan Zhi Wang, Hui Shu Wu, Jia Ming Lan, Yuan Li, Yong Xiang Wang. The synthesis and biological evaluation of a series of novel 2-COOC₂H₅/COONa substituted 1,5-benzothiazepine derivatives as antimicrobial agents[J]. Chinese Chemical Letters, ;2009, 20(6): 660-662. doi: 10.1016/j.cclet.2009.01.003 shu

The synthesis and biological evaluation of a series of novel 2-COOC₂H₅/COONa substituted 1,5-benzothiazepine derivatives as antimicrobial agents

a The College of Chemistry & Material Science, Hebei Normal University, Shijiazhuang 050016, China;
b Department of Pathogenic Biology, Hebei Medical University, Shijiazhuang 050017, China

Received Date: 27 October 2008

Fund Project: The authors are grateful for the financial support from National Natural Science Foundation of China (No.20772021) and the Natural Science Foundation of Hebei Province, China (No.2007000239).

A series of novel 1,5-benzothiazepine derivatives containing COOC₂H₅/COONa groups at the C(2)-position were synthesized and evaluated for their antifungal and antibacterial activities by both disc diffusion and minimal inhibition concentration (MIC) methods. Most of the compounds have been shown to have moderate to good antibacterial activity against S. aureus, S. epidermidis and excellent antifungal activity against C. albicans.
- 1,5-Benzothiazepine,
- Antifungal,
- Antibacterial activities
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