Citation: Chan Yu Zhang, Yan Feng Luo, Su Jun Wang, Zhao Liu, Yuan Liang Wang, Zhi Qing Liang. Design,synthesis and characterization of novel biodegradable macrodiols based on poly(DL-lactic acid) and poly (p-dioxanone)[J]. Chinese Chemical Letters, ;2009, 20(6): 743-746. doi: 10.1016/j.cclet.2008.12.055 shu

Design,synthesis and characterization of novel biodegradable macrodiols based on poly(DL-lactic acid) and poly (p-dioxanone)

a College of Bioengineering, Chongqing University, Research Center of Bioinspired Material Science and Engineering (BIMSEC), Chongqing 400030, China;
b Department of Gynecology and Obstetrics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China

Received Date: 17 October 2008

Fund Project: This study was supported by the National Key Technologies R&D Program of China (No.2006BA103B04) and the Natural Key Scientific and Technological Project of Chongqing (No.CSTC 2008AB0027).

Integrating poly(lactic acid) (PLA), glycolic acid (GA) and ethylene glycol (EG) will hopefully result in a novel copolymer that combines such advantages as fastened and controllable release rate and improved flexibility together with good biocompatibility. In this study, p-dioxanone (PDO) was employed to copolymerize with DL-lactide (LA) via ring-opening melt polymerization using Sn(Oct)₂ as an initiator and ethylene glycol as a co-initiator. The obtained degradable macrodiols (HO-P(LA-co-PDO)-OH) were just such a copolymer consisting of PLA, GA and EG. ¹H NMR was employed to characterize the copolymers, and the effect of PDO/LA molar ratios in the feedstock on the molecular weights of HO-P(LA-co-PDO)-OH was investigated by means of endhydroxyl analysis, ¹H NMR or GPC-MALLs. The results confirmed the successful synthesis of HO-P(LA-co-PDO)-OH and revealed that one end-hydroxyl of the micarodiols was donated by LA or PDO and the other one by the co-initiator EG. In addition,the molecular weights of HO-P(LA-co-PDO)-OH increased with decreasing PDO/LA ratios.
- Macrodiol,
- Poly(lactici acid),
- p-Dioxanone,
- Ethylene glycol,
- Drug delivery carrier,
- Bone morphogenetic protein
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