引用本文:
Shan Qian, Xiao Juan Ye, Fan Zheng, Li Yang, Yong Wu. Synthesis of (S) and (R)-tilisolol hydrochloride[J]. Chinese Chemical Letters,
2009, 20(6): 648-650.
doi:
10.1016/j.cclet.2008.12.048
Citation: Shan Qian, Xiao Juan Ye, Fan Zheng, Li Yang, Yong Wu. Synthesis of (S) and (R)-tilisolol hydrochloride[J]. Chinese Chemical Letters, 2009, 20(6): 648-650. doi: 10.1016/j.cclet.2008.12.048
Citation: Shan Qian, Xiao Juan Ye, Fan Zheng, Li Yang, Yong Wu. Synthesis of (S) and (R)-tilisolol hydrochloride[J]. Chinese Chemical Letters, 2009, 20(6): 648-650. doi: 10.1016/j.cclet.2008.12.048
Synthesis of (S) and (R)-tilisolol hydrochloride
摘要:
Tilisolol hydrochloride 1, a non-selective β-adrenoceptor blocker, was developed as a drug for the treatment of hypertension and angina pectoris. The optical active forms of 1, 1a and 1b were synthesized from inexpensive phthalic anhydride 2 in eight steps with 13% (S) and 15% (R) overall yield.
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关键词:
- Tilisolol hydrochloride
- / Optical
- / Synthesis
English
Synthesis of (S) and (R)-tilisolol hydrochloride
Abstract:
Tilisolol hydrochloride 1, a non-selective β-adrenoceptor blocker, was developed as a drug for the treatment of hypertension and angina pectoris. The optical active forms of 1, 1a and 1b were synthesized from inexpensive phthalic anhydride 2 in eight steps with 13% (S) and 15% (R) overall yield.
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Key words:
- Tilisolol hydrochloride
- / Optical
- / Synthesis
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