Citation: Arash Ghorbani-Choghamarani, Hamid Goudarziafshar, Somaieh Rezaee, Saiedeh Shima Mortazavi. Chemoselective N-nitrosation of secondary amines under heterogeneous and mild conditions via in situ generation of HNO₂[J]. Chinese Chemical Letters, ;2009, 20(4): 415-419. doi: 10.1016/j.cclet.2008.12.044 shu

Chemoselective N-nitrosation of secondary amines under heterogeneous and mild conditions via in situ generation of HNO₂

a Department of Chemistry, Faculty of Science, Ilam University, P. O. Box 69315516, Ilam, Iran;
b Islamic Azad University, Science and Research, Branch-Ahvaz, Ahvaz, Iran

Received Date: 26 September 2008

Fund Project: Financial support for this work by the research affairs of Ilam University, Ilam, Iran is gratefully acknowledged.

A wide variety of secondary amines are chemoselectively subjected to N-nitrosation reaction with treatment of citric acid and NaNO₂ in the presence of wet SiO₂ (50%, w/w) in dichloromethane at room temperatture under heterogeneous conditions. The N-nitrosation method is very simple and products can be easily isolated with good to high yields.
- N-Nitrosation,
- Secondary amines,
- Heterogeneous,
- Citric acid,
- NaNO₂
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