Citation: Yu Juan Gan, Wen Li Mei, You Xing Zhao, Hao Fu Dai. A new cytotoxic cardenolide from the latex of Antiaris toxicaria[J]. Chinese Chemical Letters, ;2009, 20(4): 450-452. doi: 10.1016/j.cclet.2008.12.043 shu

A new cytotoxic cardenolide from the latex of Antiaris toxicaria

a Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;
b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China

Received Date: 29 August 2008

Fund Project: This research was financially supported by National Natural Science Foundation of China (No. 30860345), National Basic Research Program of China (No. 2007CB116306), National Nonprofit Institute Research Grant of CATAS-ITBB (No. ITBBZD200744), and the Natural Science Foundation of Hainan (Nos. 80671, 30608).

A new cardenolide, toxicarioside E (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of spectral data and chemical evidence. Compound 1 showed significant cytotoxicity against K562 and SGC-7901 cell lines in vitro by MTT method with the IC₅₀ value of 0.026 and 0.027μg/mL, respectively.
- Antiaris toxicaria,
- Moraceae,
- Toxicarioside E,
- Cardenolide,
- Cytotoxicity
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