引用本文:
Feng Xiao, Yadong Xue, Yu Luo, Bo Zhang, Wei Lu, Bo Yang. Synthesis and cytotoxic activity of 7-alkynyl camptothecin derivatives[J]. Chinese Chemical Letters,
2009, 20(5): 566-568.
doi:
10.1016/j.cclet.2008.12.019
Citation: Feng Xiao, Yadong Xue, Yu Luo, Bo Zhang, Wei Lu, Bo Yang. Synthesis and cytotoxic activity of 7-alkynyl camptothecin derivatives[J]. Chinese Chemical Letters, 2009, 20(5): 566-568. doi: 10.1016/j.cclet.2008.12.019
Citation: Feng Xiao, Yadong Xue, Yu Luo, Bo Zhang, Wei Lu, Bo Yang. Synthesis and cytotoxic activity of 7-alkynyl camptothecin derivatives[J]. Chinese Chemical Letters, 2009, 20(5): 566-568. doi: 10.1016/j.cclet.2008.12.019
Synthesis and cytotoxic activity of 7-alkynyl camptothecin derivatives
摘要:
Several 7-alkynyl camptothecin derivatives were prepared via Sonogashira coupling. And anti-tumor activities of these compounds were evaluated against human esophageal cancer cell line (Eca-109), human chronic myeloid leukaemia cell line (K562), bladder cancer cell line (5637) and gastric cell line (SGC7901). Compounds 9a-d and 10a exhibited remarkable in vitro cytotoxic activity, compared with topotecan.
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关键词:
- Camptothecin
- / Anticancer
- / Synthesis
English
Synthesis and cytotoxic activity of 7-alkynyl camptothecin derivatives
Abstract:
Several 7-alkynyl camptothecin derivatives were prepared via Sonogashira coupling. And anti-tumor activities of these compounds were evaluated against human esophageal cancer cell line (Eca-109), human chronic myeloid leukaemia cell line (K562), bladder cancer cell line (5637) and gastric cell line (SGC7901). Compounds 9a-d and 10a exhibited remarkable in vitro cytotoxic activity, compared with topotecan.
-
Key words:
- Camptothecin
- / Anticancer
- / Synthesis
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