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Citation: Lin Shan Bai, Yan Wang, Xin Hua Liu, Hai Liang Zhu, Bao An Song. Novel dihydropyrazole derivatives linked with multi(hetero)aromatic ring: Synthesis and antibacterial activity[J]. Chinese Chemical Letters, ;2009, 20(4): 427-430. doi: 10.1016/j.cclet.2008.12.013 shu

Novel dihydropyrazole derivatives linked with multi(hetero)aromatic ring: Synthesis and antibacterial activity

a Key Laboratory of Anhui Educational Department, Anhui University of Technology, Maanshan 243002, China;
b State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China;
c Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China

Received Date: 10 October 2008

Fund Project: The authors wish to thank the opening foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, (No. 2008GDGP0105). The work was also supported by the Young College Teachers Research Projects of Anhui Province (No. 2008JQ1030) and to thank the Young College Teachers Research Projects of Anhui University of Technology (No. QZ200809).

Eight novel heterocycle-substituted dihydropyrazole derivatives were synthesized and characterized by ESI-MS, ¹H NMR and ¹³C NMR. All of the compounds have been screened for their antibacterial potential in vitro against Bacillus subtilis,Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The results show that compounds 9b, 9g and 9h displayed significant activity with MIC values in the range of 0.39-1.562 mg/mL against B. subtilis.
- Synthesis,
- Multi(hetero)aromatic pyrazole,
- Antibacterial activity
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