Citation: Fei Ma, Gang LÜ, Wei Fen Zhou, Qiu Juan Wang, Yi Hua Zhang, Qi Zheng Yao. Synthesis and biological evaluation of 2,4-diaminopteridine derivatives as nitric oxide synthase inhibitor[J]. Chinese Chemical Letters, ;2009, 20(4): 420-422. doi: 10.1016/j.cclet.2008.12.012 shu

Synthesis and biological evaluation of 2,4-diaminopteridine derivatives as nitric oxide synthase inhibitor

School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

Received Date: 25 September 2008

A series of novel 2,4-diamino-pteridines (9a-l) were synthesized and evaluated as inhibitors of inducible nitric oxide synthase (iNOS) in vitro. It was found that 9a, 9d, 9e, 9h, 9i and 9l showed potent inhibitory activities similar to that of methotrexate (MTX),while the activities of 9b, 9c, 9f, 9g, 9j and 9k are stronger than MTX.
- Nitric oxide,
- Tetrahydrobiopterin,
- Nitric oxide synthase,
- Synthesis,
- Inhibitive activity
1. [1]
  Ming Sheng Feng , Ping Guo , Li Xun Jiang , Jing Bo Shi , Yu Ping Cao , Qi Zheng Yao . Synthesis of novel methotrexate derivatives with inhibition activity of nitric oxide synthase. Chinese Chemical Letters, 2009, 20(2): 178-180. doi: 10.1016/j.cclet.2008.10.027
2. [2]
  Li Chen , Wen Qiu , Jia Tang , Zhi Feng Wang , Shu Ying He . Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives. Chinese Chemical Letters, 2011, 22(4): 413-416. doi: 10.1016/j.cclet.2010.10.036
3. [3]
  Qing Liu , Lin Xue , Dong-Jian Zhu , Guo-Ping Li , Hua Jiang . Highly selective two-photon fluorescent probe for imaging of nitric oxide in living cells. Chinese Chemical Letters, 2014, 25(1): 19-23.
4. [4]
  Rui Li , Wen Tao Wu , Guai Li Wu , Yuan Fan , Long Min Wu . Oxidative aromatization of 3, 5-disubstituted 2-isoxazolines by nitric oxide. Chinese Chemical Letters, 2007, 18(7): 788-790. doi: 10.1016/j.cclet.2007.05.006
5. [5]
  Jing Bo Shi , Song Xu , Ya Ping Wang , Jing Jing Li , Qi Zheng Yao . Synthesis of new pyrimidine nucleoside derivatives with nitric oxide donors for antiviral activity. Chinese Chemical Letters, 2011, 22(8): 899-902. doi: 10.1016/j.cclet.2011.01.010
6. [6]
  Yan Chun Zhang , Jin Pei Zhou , Xiao Ming Wu , Wei Hong Pan . Synthesis and antitumor activity of nitric oxide releasing derivatives of AT1 antagonist. Chinese Chemical Letters, 2009, 20(3): 302-305. doi: 10.1016/j.cclet.2008.11.012
7. [7]
  Jing Bo Shi , Jing Gao , Ya Ping Wang , Qi Zheng Yao . Synthesis and antiviral activity of 4H-[1,2,5]oxadiazolo [3,4-d]pyrimidine-5,7-dione 1-oxide nucleosides. Chinese Chemical Letters, 2009, 20(4): 404-406. doi: 10.1016/j.cclet.2008.12.009
8. [8]
  Feng Wei , Qiao Qing-Long , Leng Shuang , Miao Lu , Yin Wen-Ting , Wang Li-Qiu , Xu Zhao-Chao . A 1, 8-naphthalimide-derived turn-on fluorescent probe for imaging lysosomal nitric oxide in living cells. Chinese Chemical Letters, 2016, 27(9): 1554-1558. doi: 10.1016/j.cclet.2016.06.016
9. [9]
  Ming-Dong Lu , Xiao Zhou , Yao-Jun Yu , Pi-Hong Li , Wei-Jian Sun , Cheng-Guang Zhao , Zhi-Qiang Zheng , Tao You , Fei-Hai Wang . Synthesis and in vitro biological evaluation of nitric oxide-releasing derivatives of hydroxylcinnamic acids as anti-tumor agents. Chinese Chemical Letters, 2013, 24(05): 415-418.
10. [10]
  Xi Wang , Yi-Jun Yang , Ying Ma , Jian-Nian Yao . Controlled synthesis of multi-shelled transition metal oxide hollow structure through one-pot solution route. Chinese Chemical Letters, 2013, 24(01): 1-6.
11. [11]
  Jun Min HUANG , Ru Yu CHEN . An Efficient Synthesis of 2-Propyl-5-phenyl-1,4-dioxo-1,2,3,4,5,6,7,8-octahydro-[1,4,2] diazaphosphorino[1,2-a] [1,3,2] benzodiazaphosphorine 3-oxide. Chinese Chemical Letters, 2001, 12(12): 1071-1074.
12. [12]
  Ke Gui Yu , Dong Hong Li , Cheng He Zhou , Jun Lin Diao . Study on the synthesis and antimicrobial activity of novel cationic porphyrins. Chinese Chemical Letters, 2009, 20(4): 411-414. doi: 10.1016/j.cclet.2008.11.030
13. [13]
  Qin Zhang , Yao Fu , Hao Wei Wang , Tao Gong , Yong Qin , Zhi Rong Zhang . Synthesis and cytotoxic activity of novel curcumin analogues. Chinese Chemical Letters, 2008, 19(3): 281-285. doi: 10.1016/j.cclet.2007.12.035
14. [14]
  Xu-Feng Cao , Wen-Jing Chu , Yong-Bing Cao , Yu-She Yang . Design and synthesis of novel antifungal triazole derivatives with good activity and water solubility. Chinese Chemical Letters, 2013, 24(4): 303-306.
15. [15]
  Yin-Bo Chen , Ji-Ling Li , Xu-Sheng Shao , Xiao-Yong Xu , Zhong Li . Design, synthesis and insecticidal activity of novel anthranilic diamides with benzyl sulfide scaffold. Chinese Chemical Letters, 2013, 24(8): 673-676.
16. [16]
  Le Pan , Xiu-Zhuang Li , Di-An Sun , Hui Jin , Hong-Ru Guo , Bo Qin . Design and synthesis of novel coumarin analogs and their nematicidal activity against five phytonematodes. Chinese Chemical Letters, 2016, 27(03): 375-379. doi: 10.1016/j.cclet.2016.01.029
17. [17]
  Li Qiang Fu , Chen Yu Ling , Xing Sheng Guo , Hui Li He , Yu She Yang . Synthesis and antibacterial activity of pleuromutilin derivatives with novel C(14) side chain. Chinese Chemical Letters, 2012, 23(1): 9-12. doi: 10.1016/j.cclet.2011.10.002
18. [18]
  Xue Cui Shen , Bo Jiao , Shu Tao Ma . Synthesis and antibacterial activity of 4"-O-carbamoyl analogs of clarithromycin. Chinese Chemical Letters, 2010, 21(3): 257-260. doi: 10.1016/j.cclet.2009.11.023
19. [19]
  Li Qiang Fu , Xin Sheng Guo , Xin Liu , Hui Li He , Yu Lin Wang , Yu She Yang . Synthesis and antibacterial activity of C-2 (S)-substituted pleuromutilin derivatives. Chinese Chemical Letters, 2010, 21(5): 507-510. doi: 10.1016/j.cclet.2010.01.001

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(121)
HTML views(2)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return