Citation: Ke Gui Yu, Dong Hong Li, Cheng He Zhou, Jun Lin Diao. Study on the synthesis and antimicrobial activity of novel cationic porphyrins[J]. Chinese Chemical Letters, ;2009, 20(4): 411-414. doi: 10.1016/j.cclet.2008.11.030 shu

Study on the synthesis and antimicrobial activity of novel cationic porphyrins

a State Key laboratory of Trauma, Burn and Combined Injury, The 2nd Department of Research Institute of Surgery, Dapin Hospital, Third Military Medical University, Chongqing 400042, China;
b School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China

Received Date: 18 September 2008

Fund Project: The authors would like to express thanks to the School of Pharmacy of Southwest University for their partial support to this work.

A novel series of quaternary ammonium cationic derivatives based on tetrapyridyl-porphyrin was synthesized. All the compounds were evaluated for their in vitro antibacterial activities against S. aureus, E. coli and P. aeruginosa, and antifungal activities against C. albicans, where microorganisms were exposed and unexposed to the irradiation. The results revealed that some of these compounds, especially, 3a and 4a displayed satisfactory antibacterial activity against Gram-positive bacteria S. aureus and moderate antifungal activity against C. albicans. Unfortunately, Gram-negative bacteria P. aeruginasa was resistant to all compounds. The antimicrobial activity was found to be sensitive to the functional groups attached on the aromatic ring and the complex metal in the porphyrin ring, and decreased with the increase of electron-withdrawing capability of the functional groups. These preliminary results suggested that the remarkable antibacterial efficiency against S. aureus makes these substances promising antimicrobial agents.
- Cationic porphyrin,
- Synthesis,
- Antimicrobial activity,
- Gram-positive bacteria,
- Gram-negative bacteria,
- Fungus
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