Citation:
Ke Gui Yu, Dong Hong Li, Cheng He Zhou, Jun Lin Diao. Study on the synthesis and antimicrobial activity of novel cationic porphyrins[J]. Chinese Chemical Letters,
;2009, 20(4): 411-414.
doi:
10.1016/j.cclet.2008.11.030
-
A novel series of quaternary ammonium cationic derivatives based on tetrapyridyl-porphyrin was synthesized. All the compounds were evaluated for their in vitro antibacterial activities against S. aureus, E. coli and P. aeruginosa, and antifungal activities against C. albicans, where microorganisms were exposed and unexposed to the irradiation. The results revealed that some of these compounds, especially, 3a and 4a displayed satisfactory antibacterial activity against Gram-positive bacteria S. aureus and moderate antifungal activity against C. albicans. Unfortunately, Gram-negative bacteria P. aeruginasa was resistant to all compounds. The antimicrobial activity was found to be sensitive to the functional groups attached on the aromatic ring and the complex metal in the porphyrin ring, and decreased with the increase of electron-withdrawing capability of the functional groups. These preliminary results suggested that the remarkable antibacterial efficiency against S. aureus makes these substances promising antimicrobial agents.
-
-
-
-
[1]
Xia Junmei , Wang Wenjing , Hai Xin , E Shuang , Shu Yang , Wang Jianhua . Improvement of antibacterial activity of copper nanoclusters for selective inhibition on the growth of gram-positive bacteria. Chinese Chemical Letters, 2019, 30(2): 421-424. doi: 10.1016/j.cclet.2018.07.008
-
[2]
Li Qiang Fu , Xin Sheng Guo , Xin Liu , Hui Li He , Yu Lin Wang , Yu She Yang . Synthesis and antibacterial activity of C-2 (S)-substituted pleuromutilin derivatives. Chinese Chemical Letters, 2010, 21(5): 507-510. doi: 10.1016/j.cclet.2010.01.001
-
[3]
Shankaraiah G. Konda , Baseer M. Shaikh , Sanjay A. Chavan , Bhaskar S. Dawane . Polyethylene glycol(PEG-400):An efficient and recyclable reaction medium for the synthesis of novel 1;5-benzodiazepines and their antimicrobial activity. Chinese Chemical Letters, 2011, 22(1): 65-68. doi: 10.1016/j.cclet.2010.09.012
-
[4]
Niraj K. Ladani , Divyesh C. Mungra , Manish P. Patel , Ranjan G. Patel . Microwave assisted synthesis of novel Hantzsch 1,4-dihydropyridines, acridine-l,8-diones and polyhydroquinolines bearing the tetrazolo[1,5-a]quinoline moiety and their antimicrobial activity assess. Chinese Chemical Letters, 2011, 22(12): 1407-1410. doi: 10.1016/j.cclet.2011.07.009
-
[5]
Mehul B. Kanani , Manish P. Patel . Synthesis of N-arylquinolone derivatives bearing 2-thiophenoxyquinolines and their antimicrobial evaluation. Chinese Chemical Letters, 2014, 25(7): 1073-1076. doi: 10.1016/j.cclet.2014.04.002
-
[6]
Hemali B. Lad , Rakesh R. Giri , D.I. Brahmbhatt . An efficient synthesis of some new 3-bipyridinyl substituted coumarins as potent antimicrobial agents. Chinese Chemical Letters, 2013, 24(3): 227-229.
-
[7]
Hardik H. Jardosh , Chetan B. Sangani , Manish P. Patel , Ranjan G. Patel . One step synthesis of pyrido[1,2-a]benzimidazole derivatives of aryloxypyrazole and their antimicrobial evaluation. Chinese Chemical Letters, 2013, 24(2): 123-126.
-
[8]
N.C. Desai , N.R. Shihory , G.M. Kotadiya . Facile synthesis of benzimidazole bearing 2-pyridone derivatives as potential antimicrobial agents. Chinese Chemical Letters, 2014, 25(2): 305-307.
-
[9]
Chetan B. Sangani , Divyesh C. Mungra , Manish P. Patel , Ranjan G. Patel . Synthesis and in vitro antimicrobial screening of new pyrano[4,3-b]pyrane derivatives of 1H-pyrazole. Chinese Chemical Letters, 2012, 23(1): 57-60. doi: 10.1016/j.cclet.2011.09.012
-
[10]
Sunil Vodela , Raghu Vardhan Reddy Mekala , Ravinder Reddy Danda , Venkateshwarlu Kodhati . Design, synthesis and screening of some novel benzoxazole based 1, 3, 4-oxadiazoles as potential antimicrobial agents. Chinese Chemical Letters, 2013, 24(07): 625-628.
-
[11]
Nida N. Farshori , Mudasir R. Banday , Zeeshan Zahoor , Abdul Rauf . DCC/DMAP mediated esterification of hydroxy and non-hydroxy olefinic fatty acids with β-sitosterol: In vitro antimicrobial activity. Chinese Chemical Letters, 2010, 21(6): 646-650. doi: 10.1016/j.cclet.2010.01.003
-
[12]
Shu Qing LIU , Ji Qing XU , Hao Ran SUN . Novel Properties of Supramolecular Complexes Formed by Pairing Cationic Porphyrin and Anionic Metal-Oxo Cluster. Chinese Chemical Letters, 2000, 11(9): 831-834.
-
[13]
Kaushal K. Oza , Paresh N. Patel , Hasmukh S. Patel . Synthesis of some novel divalent transition metal complexes as antimicrobials. Chinese Chemical Letters, 2011, 22(8): 935-938. doi: 10.1016/j.cclet.2011.01.025
-
[14]
Zhi Chuan Shi , Zhi Gang Zhao , Xing Li Liu , Yu Chen . Synthesis of new hyodeoxycholic acid thiosemicarbazone derivatives under solvent-free conditions using microwave. Chinese Chemical Letters, 2011, 22(4): 405-408. doi: 10.1016/j.cclet.2010.10.020
-
[15]
Hemalatha Gadegoni , Sarangapani Manda . Synthesis and screening of some novel substituted indoles contained 1,3,4-oxadiazole and 1,2,4-triazole moiety. Chinese Chemical Letters, 2013, 24(2): 127-130.
-
[16]
Paresh N. Patel , Khyati D. Patel , Hasmukh S. Patel . Synthesis and biological study of novel 5-{(4-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)-methyl}-quinolin-8-ol and its metal complexes. Chinese Chemical Letters, 2011, 22(11): 1297-1230. doi: 10.1016/j.cclet.2011.05.042
-
[17]
. β-cyclodextrin as a supramolecular catalyst for the synthesis of 2H-indazolo[2, 1-b]phthalazine-trione derivatives in water and their antimicrobial activities. Chinese Chemical Letters, 2017, 28(7): 1577-1582. doi: 10.1016/j.cclet.2017.03.007
-
[18]
Jing Wen , Yun-Lei Luo , Hui-Zhen Zhang , Huan-Huan Zhao , Cheng-He Zhou , Gui-Xin Cai . A green and convenient approach toward benzimidazole derivatives and their antimicrobial activity. Chinese Chemical Letters, 2016, 27(03): 391-394. doi: 10.1016/j.cclet.2015.12.014
-
[19]
Simone Véronique Fannang , Victor Kuete , Céline Mbazoa Djama , Marlise Diane J. Dongfack , Jean Duplex Wansi , François Tillequin , Elisabeth Seguin , Elizabeth Chosson , Jean Wandji . A new friedelane triterpenoid and saponin with moderate antimicrobial activity from the stems of Drypetes laciniata. Chinese Chemical Letters, 2011, 22(2): 171-174. doi: 10.1016/j.cclet.2010.09.022
-
[20]
Yue Gai , Ling Ling Zhao , Chang Qi Hu , Hui Ping Zhang . Fusarielin E, a new antifungal antibiotic from Fusarium sp.. Chinese Chemical Letters, 2007, 18(8): 954-956. doi: 10.1016/j.cclet.2007.05.048
-
[1]
Metrics
- PDF Downloads(0)
- Abstract views(155)
- HTML views(4)