Citation: Fang Zhao, Jun Hai Xiao, Ying Wang, Song Li. Synthesis of thiourea derivatives as CCR4 antagonists[J]. Chinese Chemical Letters, ;2009, 20(3): 296-299. doi: 10.1016/j.cclet.2008.11.029 shu

Synthesis of thiourea derivatives as CCR4 antagonists

Fang Zhao ^a,b, ,
Jun Hai Xiao ^b ,
Ying Wang ^c ,
Song Li ^b

a School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;
b Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;
c Center for Human Disease Genomics, Peking University, Beijing 100083, China

Received Date: 3 September 2008

Fund Project: We appreciate PKU human disease genomics center for their unconditional support. This work was financially supported by the National High-Tech Research and Development Program of China (863 Program) (No. 2006AA10A201) and National Natural Science Foundation (No. 30472093).

A series of thiourea derivatives have been synthesized. Their structures were confirmed by MS and ¹H NMR. Several compounds showed potent activities as antagonists of CCR4 receptor.
- CCR4 antagonists,
- Thiourea derivatives,
- Synthesis
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