Citation: Jian Wang, Xiao Ya Yuan, Jin Yue Wang, Shu Hua Chen. Design and synthesis of chiral single-armed molecular tweezers derived from α-hyodeoxycholic acid[J]. Chinese Chemical Letters, ;2009, 20(3): 265-268. doi: 10.1016/j.cclet.2008.11.028 shu

Design and synthesis of chiral single-armed molecular tweezers derived from α-hyodeoxycholic acid

a Department of Chemistry and Chemical Engineering, Yibin University, Yibin 644007, China;
b College of Science, Chongqing Jiaotong University, Chongqing 400074, China;
c College of Chemistry, Sichuan University, Chengdu 610064, China

Received Date: 11 June 2008

Fund Project: We are very grateful to the financial support from National Natural Science Foundation of China (No. 20272038).

A novel type of molecular tweezers with different chiral center and cleft has been designed and prepared by using α-hyodeoxycholic acid as spacer and D/L-amino acid methyl ester as chiral arm attached at 3-position. Their structures were elucidated by ¹H NMR, FTIR and elemental analysis. Their recognition properties for various D/L-amino acid methyl esters were also investigated. The preliminary results indicated that these chiral single-armed molecular tweezers exhibited good recognition ability for D/L-amino acid methyl esters with high association constant (up to 5.24×10³ L mol^-1).
- α-Hyodeoxycholic acid,
- Molecular tweezers,
- Synthesis,
- Recognition
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