Citation: Liang Li, Hong Liu, Xian Dong Xu, Yong Su Zhen. A novel derivative of geldanamycin and its antitumor activity[J]. Chinese Chemical Letters, ;2009, 20(4): 391-392. doi: 10.1016/j.cclet.2008.11.011 shu

A novel derivative of geldanamycin and its antitumor activity

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Received Date: 9 September 2008

A new derivative of geldanamycin was synthesized by introducing the 6-cinnamamido-hexyl-amino group into the 17-site of geldanamycin, a heat shock protein 90(Hsp90) inhibitor, to obtain 17-(6-cinnamamido-hexylamino)-17-demethoxygel-danamycin (CNDG). Its in vitro and in vivo antitumor effects were evaluated by MTT assay and xenograft in nude mice.
- 17-(6-Cinnamamido-hexylamino)-17-demethoxygeldanamycin,
- Hsp90 inhibitor
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