引用本文:
Jie Li, Li Hai, Wei Jia Liu, Xiao Chun Wu, Yong Wu. Study on synthesis and distribution in vivo of 5-Fu-cholic acid conjugate[J]. Chinese Chemical Letters,
2009, 20(2): 136-138.
doi:
10.1016/j.cclet.2008.11.004
Citation: Jie Li, Li Hai, Wei Jia Liu, Xiao Chun Wu, Yong Wu. Study on synthesis and distribution in vivo of 5-Fu-cholic acid conjugate[J]. Chinese Chemical Letters, 2009, 20(2): 136-138. doi: 10.1016/j.cclet.2008.11.004
Citation: Jie Li, Li Hai, Wei Jia Liu, Xiao Chun Wu, Yong Wu. Study on synthesis and distribution in vivo of 5-Fu-cholic acid conjugate[J]. Chinese Chemical Letters, 2009, 20(2): 136-138. doi: 10.1016/j.cclet.2008.11.004
Study on synthesis and distribution in vivo of 5-Fu-cholic acid conjugate
摘要:
A series of hepatic targeting drugs, 5-Fu-cholic acid conjugate T1-T5, were synthesized. 5-Fu and cholic acid was selected as starting material, after N-hydroxymethylation, condensation, hydrogenolysis to obtain carboxylated 5-Fu 5a-e. Carboxylated 5-Fu 5a-e were condensated with intermediate 3-hydroxyethyl cholic acid benzyl ester 6 to get 7a-e, 7a-e were deprotected to get T1-T5.
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关键词:
- Hepatic targeting drugs
- / Cholic acid
- / Synthesis
English
Study on synthesis and distribution in vivo of 5-Fu-cholic acid conjugate
Abstract:
A series of hepatic targeting drugs, 5-Fu-cholic acid conjugate T1-T5, were synthesized. 5-Fu and cholic acid was selected as starting material, after N-hydroxymethylation, condensation, hydrogenolysis to obtain carboxylated 5-Fu 5a-e. Carboxylated 5-Fu 5a-e were condensated with intermediate 3-hydroxyethyl cholic acid benzyl ester 6 to get 7a-e, 7a-e were deprotected to get T1-T5.
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Key words:
- Hepatic targeting drugs
- / Cholic acid
- / Synthesis
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