引用本文:
Yan Yang, Hong Gang Hu, Qing Jie Zhao, Shi Chong Yu, Zhi Gang Dan, Yan Zou, Qiu Ye Wu. One-pot synthesis of 7-bromo-1-[4-(1-cyano-1-methylethyl)]-phenyl-[1,2,4]-triazole-[4,3-a]-quinoxalin[J]. Chinese Chemical Letters,
2009, 20(1): 52-54.
doi:
10.1016/j.cclet.2008.10.019
Citation: Yan Yang, Hong Gang Hu, Qing Jie Zhao, Shi Chong Yu, Zhi Gang Dan, Yan Zou, Qiu Ye Wu. One-pot synthesis of 7-bromo-1-[4-(1-cyano-1-methylethyl)]-phenyl-[1,2,4]-triazole-[4,3-a]-quinoxalin[J]. Chinese Chemical Letters, 2009, 20(1): 52-54. doi: 10.1016/j.cclet.2008.10.019
Citation: Yan Yang, Hong Gang Hu, Qing Jie Zhao, Shi Chong Yu, Zhi Gang Dan, Yan Zou, Qiu Ye Wu. One-pot synthesis of 7-bromo-1-[4-(1-cyano-1-methylethyl)]-phenyl-[1,2,4]-triazole-[4,3-a]-quinoxalin[J]. Chinese Chemical Letters, 2009, 20(1): 52-54. doi: 10.1016/j.cclet.2008.10.019
One-pot synthesis of 7-bromo-1-[4-(1-cyano-1-methylethyl)]-phenyl-[1,2,4]-triazole-[4,3-a]-quinoxalin
摘要:
[1,2,4]-Triazole-[4,3-a]-quinoxaline is an important component of many drugs. The yield of the reported methods for triazole cyclization step was usually as low as 20%. In this article, the triazole cyclization step was successfully done by using microwave method with a high yield of 75% for the first time.
English
One-pot synthesis of 7-bromo-1-[4-(1-cyano-1-methylethyl)]-phenyl-[1,2,4]-triazole-[4,3-a]-quinoxalin
Abstract:
[1,2,4]-Triazole-[4,3-a]-quinoxaline is an important component of many drugs. The yield of the reported methods for triazole cyclization step was usually as low as 20%. In this article, the triazole cyclization step was successfully done by using microwave method with a high yield of 75% for the first time.
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Key words:
- [1,2,4]-Triazole-[4,3-a]-quinoxaline
- / Microwave
- / Synthesis
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