引用本文:
Shivaji S. Pawar, Murlidhar S. Shingare, Shivaji N. Thore. Novel, efficient, and green procedure for the synthesis of 1,5-benzodiazepines catalyzed by MgBr2 in aqueous media[J]. Chinese Chemical Letters,
2009, 20(1): 32-36.
doi:
10.1016/j.cclet.2008.10.015
Citation: Shivaji S. Pawar, Murlidhar S. Shingare, Shivaji N. Thore. Novel, efficient, and green procedure for the synthesis of 1,5-benzodiazepines catalyzed by MgBr2 in aqueous media[J]. Chinese Chemical Letters, 2009, 20(1): 32-36. doi: 10.1016/j.cclet.2008.10.015
Citation: Shivaji S. Pawar, Murlidhar S. Shingare, Shivaji N. Thore. Novel, efficient, and green procedure for the synthesis of 1,5-benzodiazepines catalyzed by MgBr2 in aqueous media[J]. Chinese Chemical Letters, 2009, 20(1): 32-36. doi: 10.1016/j.cclet.2008.10.015
Novel, efficient, and green procedure for the synthesis of 1,5-benzodiazepines catalyzed by MgBr2 in aqueous media
摘要:
MgBr2 performs as a novel catalyst for the synthesis of various 1,5-benzodiazepine derivatives from wide range of substituted o-phenylenediamines and various ketones in good to excellent isolated yields (93-98%) using water as solvent at ambient temperature. Several solvents were examined for this reaction; however, in terms of reaction yield and time, water was found to be the optimum solvent. The remarkable advantages offered by this method are easily and inexpensive available catalyst, simple procedure, mild conditions, much faster (40-60 min) reactions and good to excellent yields of products.
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关键词:
- MgBr2
- / o-Phenylenediamines
- / Ketones
- / Aqueous media
- / 1,5-Benzodiazepine
English
Novel, efficient, and green procedure for the synthesis of 1,5-benzodiazepines catalyzed by MgBr2 in aqueous media
Abstract:
MgBr2 performs as a novel catalyst for the synthesis of various 1,5-benzodiazepine derivatives from wide range of substituted o-phenylenediamines and various ketones in good to excellent isolated yields (93-98%) using water as solvent at ambient temperature. Several solvents were examined for this reaction; however, in terms of reaction yield and time, water was found to be the optimum solvent. The remarkable advantages offered by this method are easily and inexpensive available catalyst, simple procedure, mild conditions, much faster (40-60 min) reactions and good to excellent yields of products.
-
Key words:
- MgBr2
- / o-Phenylenediamines
- / Ketones
- / Aqueous media
- / 1,5-Benzodiazepine
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