Determination of ephedrine and codeine in human urine by cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography

Li Jun Li Si Guang Li Hai Yan Li Zhuo Cai Hao Cheng

引用本文: Li Jun Li,  Si Guang Li,  Hai Yan Li,  Zhuo Cai,  Hao Cheng. Determination of ephedrine and codeine in human urine by cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography[J]. Chinese Chemical Letters, 2009, 20(1): 84-87. doi: 10.1016/j.cclet.2008.10.014 shu
Citation:  Li Jun Li,  Si Guang Li,  Hai Yan Li,  Zhuo Cai,  Hao Cheng. Determination of ephedrine and codeine in human urine by cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography[J]. Chinese Chemical Letters, 2009, 20(1): 84-87. doi: 10.1016/j.cclet.2008.10.014 shu

Determination of ephedrine and codeine in human urine by cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography

  • 基金项目:

    This project was supported by the Guangxi Provincial Foundation of Natural Science (No. 0481019).

摘要: A sensitive method for the determination of ephedrine and codeine in human urine by capillary electrophoresis (CE) was described. In order to improve the sensitivity, two online concentration techniques including cation-selective exhaustive injection (CSEI) and sweeping micellar electrokinetic chromatography (sweeping-MEKC) were used. Under the optimum conditions, the detection limits (S/N=3) were 0.10 μg/L for ephedrine and 0.80 μg/L for codeine. This method was successfully applied to real urine sample analysis.

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  • 收稿日期:  2008-06-17
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