引用本文:
Jiang Jiang, Qiong Jie Wu, Xiang Yang Cai, Long Gen Zhu, Wen Ji Wang. Mass spectrometry assisted assignments of binding and cleavage sites of Zn(Ⅱ) complex towards oxidized insulin B chain[J]. Chinese Chemical Letters,
2009, 20(1): 71-75.
doi:
10.1016/j.cclet.2008.09.043
Citation: Jiang Jiang, Qiong Jie Wu, Xiang Yang Cai, Long Gen Zhu, Wen Ji Wang. Mass spectrometry assisted assignments of binding and cleavage sites of Zn(Ⅱ) complex towards oxidized insulin B chain[J]. Chinese Chemical Letters, 2009, 20(1): 71-75. doi: 10.1016/j.cclet.2008.09.043
Citation: Jiang Jiang, Qiong Jie Wu, Xiang Yang Cai, Long Gen Zhu, Wen Ji Wang. Mass spectrometry assisted assignments of binding and cleavage sites of Zn(Ⅱ) complex towards oxidized insulin B chain[J]. Chinese Chemical Letters, 2009, 20(1): 71-75. doi: 10.1016/j.cclet.2008.09.043
Mass spectrometry assisted assignments of binding and cleavage sites of Zn(Ⅱ) complex towards oxidized insulin B chain
摘要:
The electrospray ionization mass spectrometry investigation showed that the binding sites of [ZnL]2+, where L is 2-[bis(2-aminoethyl)amino]ethanol, with oxidized insulin B chain are Phe1, His5 and Arg22, which lead to the selective cleavages of the peptide bonds at Phe1-Val2, His5-Leu6, Glu21-Arg22, and Arg22-Gly23 of oxidized insulin B chain.
English
Mass spectrometry assisted assignments of binding and cleavage sites of Zn(Ⅱ) complex towards oxidized insulin B chain
Abstract:
The electrospray ionization mass spectrometry investigation showed that the binding sites of [ZnL]2+, where L is 2-[bis(2-aminoethyl)amino]ethanol, with oxidized insulin B chain are Phe1, His5 and Arg22, which lead to the selective cleavages of the peptide bonds at Phe1-Val2, His5-Leu6, Glu21-Arg22, and Arg22-Gly23 of oxidized insulin B chain.
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Key words:
- Oxidized insulin B chain
- / Zn(Ⅱ)complex
- / Mass spectrometry
- / Hydrolytic cleavage
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