Citation: Mudasir R. Banday, Abdul Rauf. Synthesis and evaluation of in vitro antibacterial activity of novel 2,5-disubstituted-1,3,4-thiadiazoles from fatty acids[J]. Chinese Chemical Letters, ;2008, 19(12): 1427-1430. doi: 10.1016/j.cclet.2008.09.029 shu

Synthesis and evaluation of in vitro antibacterial activity of novel 2,5-disubstituted-1,3,4-thiadiazoles from fatty acids

Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India

Received Date: 11 June 2008

Fund Project: Authors are thankful to Chairman, Department of Chemistry, A.M.U, Aligarh for providing necessary research facilities.

A series of new 1-(alkenoyl/hydroxyalkenoyl)-4-benzoyl-thiosemicarbazides 2a-d and 2-benzamide-5-alkenyl/hydroxyalk-enyl-1,3,4-thiadiazoles 3a-d were synthesized from fatty acid hydrazides. Structure of all these compounds was confirmed by IR, ¹H NMR, ¹³C NMR, mass spectra and elemental analysis. The bioassay results indicate that some compounds 2c, 2d, 3c and 3d have good antibacterial activity.
- Aroylthioserniearbazide,
- 1,3,4-Thiadiazole,
- Antibacterial activity
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