Synthesis and antibacterial activities of pleuromutilin derivatives

Yuan Yuan Zhang Ke Ping Xu Dan Ren Shao Rong Ge Yu Liang Wang Yu Zhong Wang

引用本文: Yuan Yuan Zhang,  Ke Ping Xu,  Dan Ren,  Shao Rong Ge,  Yu Liang Wang,  Yu Zhong Wang. Synthesis and antibacterial activities of pleuromutilin derivatives[J]. Chinese Chemical Letters, 2009, 20(1): 29-31. doi: 10.1016/j.cclet.2008.09.009 shu
Citation:  Yuan Yuan Zhang,  Ke Ping Xu,  Dan Ren,  Shao Rong Ge,  Yu Liang Wang,  Yu Zhong Wang. Synthesis and antibacterial activities of pleuromutilin derivatives[J]. Chinese Chemical Letters, 2009, 20(1): 29-31. doi: 10.1016/j.cclet.2008.09.009 shu

Synthesis and antibacterial activities of pleuromutilin derivatives

摘要: Six new pleuromutilin derivatives were designed and synthesized, confirmed by MS, IR and 1H NMR techniques. And the antibacterial activities were primarily evaluated in vitro. The results indicated that most of the derivatives showed more potent activities against corresponding bacterial strains than that of pleuromutilin. Especially, compounds 4d and 5b had obvious activities against salmonella compared with pleuromutilin.

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  • 收稿日期:  2008-06-11
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