引用本文:
Yuan Yuan Zhang, Ke Ping Xu, Dan Ren, Shao Rong Ge, Yu Liang Wang, Yu Zhong Wang. Synthesis and antibacterial activities of pleuromutilin derivatives[J]. Chinese Chemical Letters,
2009, 20(1): 29-31.
doi:
10.1016/j.cclet.2008.09.009
Citation: Yuan Yuan Zhang, Ke Ping Xu, Dan Ren, Shao Rong Ge, Yu Liang Wang, Yu Zhong Wang. Synthesis and antibacterial activities of pleuromutilin derivatives[J]. Chinese Chemical Letters, 2009, 20(1): 29-31. doi: 10.1016/j.cclet.2008.09.009

Citation: Yuan Yuan Zhang, Ke Ping Xu, Dan Ren, Shao Rong Ge, Yu Liang Wang, Yu Zhong Wang. Synthesis and antibacterial activities of pleuromutilin derivatives[J]. Chinese Chemical Letters, 2009, 20(1): 29-31. doi: 10.1016/j.cclet.2008.09.009

Synthesis and antibacterial activities of pleuromutilin derivatives
摘要:
Six new pleuromutilin derivatives were designed and synthesized, confirmed by MS, IR and 1H NMR techniques. And the antibacterial activities were primarily evaluated in vitro. The results indicated that most of the derivatives showed more potent activities against corresponding bacterial strains than that of pleuromutilin. Especially, compounds 4d and 5b had obvious activities against salmonella compared with pleuromutilin.
English
Synthesis and antibacterial activities of pleuromutilin derivatives
Abstract:
Six new pleuromutilin derivatives were designed and synthesized, confirmed by MS, IR and 1H NMR techniques. And the antibacterial activities were primarily evaluated in vitro. The results indicated that most of the derivatives showed more potent activities against corresponding bacterial strains than that of pleuromutilin. Especially, compounds 4d and 5b had obvious activities against salmonella compared with pleuromutilin.
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Key words:
- Pleuromutilin
- / Derivatives
- / Synthesis
- / Antibacterial activities

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