引用本文:
Shivaji S. Pawar, Deepak V. Dekhane, Murlidhar S. Shingare, Shivaji N. Thore. Glyoxylic acid as catalyst: A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media[J]. Chinese Chemical Letters,
2008, 19(9): 1055-1058.
doi:
10.1016/j.cclet.2008.06.028
Citation: Shivaji S. Pawar, Deepak V. Dekhane, Murlidhar S. Shingare, Shivaji N. Thore. Glyoxylic acid as catalyst: A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media[J]. Chinese Chemical Letters, 2008, 19(9): 1055-1058. doi: 10.1016/j.cclet.2008.06.028

Citation: Shivaji S. Pawar, Deepak V. Dekhane, Murlidhar S. Shingare, Shivaji N. Thore. Glyoxylic acid as catalyst: A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media[J]. Chinese Chemical Letters, 2008, 19(9): 1055-1058. doi: 10.1016/j.cclet.2008.06.028

Glyoxylic acid as catalyst: A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media
摘要:
Glyoxylic acid (5 mol%) performs as a novel highly water-soluble catalyst for the synthesis of 2-aryl-l-arylmethyl-lH-benzimidazoles from a wide range of substituted o-phenylenediamines and various substituted aldehydes in good to excellent isolated yields (85-95%) using water as solvent at ambient temperature. The remarkable advantages offered by this method are easily and inexpensive available catalyst, simple procedure, mild conditions, much faster (20-40 min) reactions and excellent yields of products.
English
Glyoxylic acid as catalyst: A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media
Abstract:
Glyoxylic acid (5 mol%) performs as a novel highly water-soluble catalyst for the synthesis of 2-aryl-l-arylmethyl-lH-benzimidazoles from a wide range of substituted o-phenylenediamines and various substituted aldehydes in good to excellent isolated yields (85-95%) using water as solvent at ambient temperature. The remarkable advantages offered by this method are easily and inexpensive available catalyst, simple procedure, mild conditions, much faster (20-40 min) reactions and excellent yields of products.

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