Citation: Hui Hui Li, Gu Yuan. Investigation of formation of dimeric G-quadruplex of HIV-1 integrase inhibitor by nuclear magnetic resonance[J]. Chinese Chemical Letters, ;2008, 19(9): 1108-1110. doi: 10.1016/j.cclet.2008.06.010 shu

Investigation of formation of dimeric G-quadruplex of HIV-1 integrase inhibitor by nuclear magnetic resonance

Hui Hui Li ,
Gu Yuan

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

Received Date: 8 April 2008

Fund Project: Project was supported by the National Natural Science Foundation of China (No. 20472009) and the Research Fund for the Doctoral Program of Higher Education.

In this research, an unusually dimeric G-quadruplex of d(GGGTGGGTGGGTGGGT) (Sl), the potent nanomolar HIV-1 integrase inhibitor, was detected by nuclear magnetic resonance (NMR). This result has been confirmed by electrospray ionization mass spectrometry (ESI-MS) and circular dichroism (CD).
- G-quadruplex,
- HIV-I integrase inhibitor,
- Nuclear magnetic resonance
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