Citation: Tao Wang, Yi Hua Zhang, Shan Yu, Hui Ji, Yi Sheng Lai, Si Xun Peng. Synthesis and biological evaluation of novel thalidomide analogues as potential anticancer drugs[J]. Chinese Chemical Letters, ;2008, 19(8): 928-930. doi: 10.1016/j.cclet.2008.05.044 shu

Synthesis and biological evaluation of novel thalidomide analogues as potential anticancer drugs

Tao Wang ^a, ,
Yi Hua Zhang ^a ,
Shan Yu ^b ,
Hui Ji ^b ,
Yi Sheng Lai ^a ,
Si Xun Peng ^a

a Center of Drug Discovery, China. Pharmaceutical University, Nanjing 210009, China;
b Department of Pharmacology, China. Pharmaceutical University, Nanjing 210009, China

Received Date: 31 March 2008

In search of novel anticancer agents, a series of thalidomide analogs (6a-j) were designed and synthesized.Cytotoxicity of these compounds against human hepatoma cells (HepG2) was evaluated by MTT method.Compounds 6d, 6h and 6i showed significant cytotoxic activities comparable to or stronger than control 5-fluorouracil.
- Thalidomide,
- 1,3,4-Thiadiazole,
- Anti-tumor activity,
- HepG2
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