Citation: Jin Du Li, Miao Chen, Sheng Liu, Hao Bo Zhang, Zhi Lu Liu. Synthesis and photoactivity of phenylazonaphthalene peptide nucleic acid monomers[J]. Chinese Chemical Letters, ;2008, 19(7): 807-810. doi: 10.1016/j.cclet.2008.05.023 shu

Synthesis and photoactivity of phenylazonaphthalene peptide nucleic acid monomers

Jin Du Li ^a,b, ,
Miao Chen ^a ,
Sheng Liu ^a,b ,
Hao Bo Zhang ^a,b ,
Zhi Lu Liu ^a,b

a Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China;
b Graduate School of Chinese Academy of Sciences, Beijing

Received Date: 7 March 2008

Fund Project: and the Innovation Group Project (No.50421502) and 973 project (No.2007CB607605) of the Chinese Ministry of Science & Technology.This work is supported from the National Nature Science Foundation of China (No.20473106)

Phenylazonaphthalene peptide nucleic acid (PNA) monomers were successfully synthesized,and their photoisomerization was examined.The new PNA monomers showed reversible trans-cis isomerization with UV and visible light irradiation,which might be the foundation of photo-regulating the hybridization between PNA containing phenylazonaphthalene unit and DNA.Simultaneously,the fluorescence of the new PNA monomers might make them especially useful as structural probes.
- Peptide nucleic acid,
- Phenylazonaphthalene,
- Photoisomerization,
- UV-vis absorption spectrometry,
- Fluorescence spectrometry
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