Citation: Yan Jiao, Zhi Jie Fang, Yu Hua Jiang, Bao Hui Zheng, Jie Cheng. Practical and concise synthesis of 2-oxo-3,4,5,6-tetraethoxyazepane from D-glucono-1,5-lactone[J]. Chinese Chemical Letters, ;2008, 19(7): 795-796. doi: 10.1016/j.cclet.2008.04.044 shu

Practical and concise synthesis of 2-oxo-3,4,5,6-tetraethoxyazepane from D-glucono-1,5-lactone

School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China

Received Date: 21 January 2008

Fund Project: This work was financially supported by the Graduate Education Innovation Foundation of Nanjing University of Science & Technology (No.200705).

2-Oxo-3R,4S,5S,6S-tetraethoxyazepane was conveniently synthesized from D-glucono-1,5-lactone with a yield of 10% overall.The key step of synthetic route-reductive 1,6-cyclization was completed efficiently by using Ph₃P to give the expected lactam.
- Azepane,
- Ph₃P,
- Reduction,
- Iminosugars,
- Glucono lactone
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