Citation:
Cherkupally Sanjeeva Reddy, Mekala Raghu. Cerium(Ⅳ) ammonium nitrate catalysed facile and efficient synthesis of polyhydroquinoline derivatives through Hantzsch multicomponent condensation[J]. Chinese Chemical Letters,
;2008, 19(7): 775-779.
doi:
10.1016/j.cclet.2008.04.040
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A general and convenient practical approach for the synthesis of polyhydroquinoline derivatives has been achieved via one-pot four-component Hantzsch condensation of aromatic aldehydes,dimedone,ethyl acetoacetate and ammonium acetate in the presence of a catalytic amount of cerium(Ⅳ) ammonium nitrate (CAN),in ethanol solvent at ambient temperature.Simple work-up,mild reaction conditions,inexpensive and non-toxic catalyst,and excellent product yields are the advantageous features of this method.
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Keywords:
- Aldehydes,
- Dimedone,
- Ethyl acetoacetate,
- Ammonium acetate,
- CAN,
- Polyhydroquinolines
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