Citation: Na Zhang, Mei Li Guo, Ge Zhang, Run Ping Li. A new neuroprotective bakkenolide from the rhizome of Petasites tricholobus[J]. Chinese Chemical Letters, ;2008, 19(7): 841-844. doi: 10.1016/j.cclet.2008.04.036 shu

A new neuroprotective bakkenolide from the rhizome of Petasites tricholobus

Na Zhang ^a, ,
Mei Li Guo ^a ,
Ge Zhang ^a ,
Run Ping Li ^b

a Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;
b Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China

Received Date: 17 January 2008

A new bakkenolide-type compound, bakkenolide-Va(1), was isolated from the rhizome of Petasites tricholobus. The structure was characterized on the basis of various NMR (¹H, ¹³C, ¹H-¹H COSY, HMQC, HMBC and NOESY) and mass spectrometry data. The neuroprotective activity of bakkenolide-Va was investigated in primarily cultured neurons treated by hypoxia-glucose deprivation and various types of oxidative insults.
- Petasites tricholobus,
- Compositae,
- Bakkenolide-Va,
- Neuroprotection

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(526)
HTML views(20)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return