Citation: Chen Xi Zhang, Guo Jun Zheng, Fu Qiang Bi, Yu Lin Li. A simple and efficient synthesis of the valsartan[J]. Chinese Chemical Letters, ;2008, 19(7): 759-761. doi: 10.1016/j.cclet.2008.04.032 shu

A simple and efficient synthesis of the valsartan

State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000, China. Received 11 December 2007

Received Date: 11 December 2007

Fund Project: This work was financially supported by the National Natural Science Foundation of China (No.20272012) and the Special Research Grant for Doctoral Sites in Chinese Universities (No.20010730001)

Valsartan 1,one of the most important agents used in antihypertensive therapy today,was synthesized starting from L-valin methyl ester hydrochloride 2 through four steps in an overall yield of 60%.The key step involves the palladium-catalyzed SuzuKi coupling.This method overcomes many of the drawbacks associated with the previously reported syntheses and is more suitable for industrial production.
- Valsartan,
- Antihypertensive,
- L-Valin methyl ester hydrochloride,
- Synthesis,
- Suzuki coupling
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