Citation: Wei Zhang, Tao Yang, Da Ming Huang, Kui Jiao. Electrochemical sensing of DNA immobilization and hybridization based on carbon nanotubes/nano zinc oxide/chitosan composite film[J]. Chinese Chemical Letters, ;2008, 19(5): 589-591. doi: 10.1016/j.cclet.2008.03.012 shu

Electrochemical sensing of DNA immobilization and hybridization based on carbon nanotubes/nano zinc oxide/chitosan composite film

College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Received Date: 30 October 2007

Fund Project: No.20375020) and Doctoral Foundation of the Ministry of Education of China (No.20060426001).This work was supported by the National Natural Science Foundation of China (No.20635020

A novel electrochemical DNA biosensor based on zinc oxide (ZnO) nanoparticles and multi-walled carbon nanotubes (MWNTs)for DNA immobilization and enhanced hybridization detection is presented. The MWNTs/nano ZnO/chitosan composite filmmodified glassy carbon electrode (MWNTs/ZnO/CHIT/GCE) was fabricated and DNA probes were immobilized on the electrodesurface. The hybridization events were monitored by differential pulse voltammetry (DPV) using methylene blue (MB) as anindicator. The sensor can effectively discriminate different DNA sequences related to PAT gene in the.transgenic corn, with adetection limit of 2.8×10^-12 mol/L of target sequence.
- ZnO nanoparticles,
- Multi-walled carbon nanotubes,
- Chitosan,
- DNA sensor,
- PAT gene
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