Citation: Da Dong Guo, Chun Hui Wu, Xue Mei Wang, Bao An Chen. Electrochemical study of the effect of functionalized nickel nanoparticles on cellular uptake of leukemia cancer cells in vitro[J]. Chinese Chemical Letters, ;2008, 19(5): 577-580. doi: 10.1016/j.cclet.2008.01.038 shu

Electrochemical study of the effect of functionalized nickel nanoparticles on cellular uptake of leukemia cancer cells in vitro

a State Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University, Nanjing 210096, China;
b Zhongda Hospital, School of Clinical Medical, Southeast University, Nanjing 210096, China

Received Date: 10 December 2007

Fund Project: 20535010 & 60121101) and the Program (No. 050462) for New Century Excellent Talents in University90713023This work has been supported by NSFC (No.20675014Ministry of Education of China.

In this study, we have fabricated the functionalized nickel nanoparticles and investigated their effects on cellular uptake ofquercetin in leukemia K562 cancer cells by using electrochemical assay. The results indicate that nickel nanoparticles couldefficiently enhance the quercetin uptake and increase the intracellular accumulation in cancer cells, implying the great potential offunctionalized nickel nanoparticles in target cancer therapy.
- Nickel nanoparticles,
- Leukemia cancer cells,
- Quercetin,
- Electrochemical assay
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