Citation: Ali Niazi, Ateesa Yazdanipour. Determination of trace amounts of morphine in human plasma by anodic adsorptive stripping differential pulse voltammetry[J]. Chinese Chemical Letters, ;2008, 19(4): 465-468. doi: 10.1016/j.cclet.2007.12.036 shu

Determination of trace amounts of morphine in human plasma by anodic adsorptive stripping differential pulse voltammetry

Department of Chemistry, Faculty of Sciences, Azad University of Arak, Arak, Iran

Received Date: 5 November 2007

New adsorptive anodic differential pulse stripping voltammetry method for the direct determination of morphine at trace levels in human plasma of addicts is proposed.The procedure involves an adsorptive accumulation of morphine on a HMDE, followed by oxidation of adsorbed morphine by voltammetry scan using differential pulse modulation.The optimum conditions for the analysis of morphine are pH 10.5, E_acc of-100 mV (vs.Ag/AgCl), and t_acc of 120 s.The peak current is proportional to the concentration of morphine, and a linear calibration graph is obtained at 0.01-3.10 μg mL^-1.A relative standard deviation of 1.06% (n=5) was obtained, and the limit of detection was 3 ng mL^-1.The capability of the method for the analysis of real samples was evaluated by the determination of morphine in spiked human plasma and addicts human plasma with satisfactory results.
- Morphine,
- Adsorptive differential pulse voltammetry,
- Human plasma
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