Citation: Chang Yan Zhao, Chang Qing Shi, Yuan Wei Chen. Synthesis of urea acetates as potential PPARα/γ dual agonists[J]. Chinese Chemical Letters, ;2008, 19(2): 166-168. doi: 10.1016/j.cclet.2007.12.013 shu

Synthesis of urea acetates as potential PPARα/γ dual agonists

a Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China;
b Graduate School of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 28 September 2007

Fund Project: The authors thank the 100 Talents program of Chinese Academy of Sciences, the Chengdu Institute of Organic Chemistry, and the Graduate School of the Chinese Academy of Sciences for financial support of this work.

In the quest for novel PPARα/γ dual agonists as putative drugs for the treatment of type 2 diabetes and dyslipidemia, we designed and synthesized a series of urea acetates as potential PPARα/γ dual agonists.The structure of the target compounds, intermediates were characterized by ¹H NMR, HRMS.
- Oxazole,
- PPAR agonist,
- Type 2 diabetes,
- Urea,
- Ammonolysis,
- Synthesis
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