Citation: Wen Cai Huang, Hu Zheng, Ling Ling Weng. Synthesis of tetracycline analogs and their bone affinities[J]. Chinese Chemical Letters, ;2008, 19(1): 19-22. doi: 10.1016/j.cclet.2007.10.048 shu

Synthesis of tetracycline analogs and their bone affinities

a School of Chemical Engineering, Sichuan University, Chengdu 610065, China;
b West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Received Date: 27 August 2007

Tetracycline analogs were designed and synthesized and their bone affinities were tested on hydroxyapatite. The results showed that the carbonyl-amide-enol structure in A ring and phenol-ketone structure in BCD ring may be responsible for tetracycline's high bone affinity and either A ring or BCD ring has a planar conformation is essential.
- Tetracycline,
- Analogs,
- Bone affinities,
- Hydroxyapatite
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