Citation: Cherkupally Sanjeeva Reddy, Adki Nagaraj. Knoevenagel condensation of α,β-unsaturated aromatic aldehydes with barbituric acid under non-catalytic and solvent-free conditions[J]. Chinese Chemical Letters, ;2007, 18(12): 1431-1435. doi: 10.1016/j.cclet.2007.10.016 shu

Knoevenagel condensation of α,β-unsaturated aromatic aldehydes with barbituric acid under non-catalytic and solvent-free conditions

Department of Chemistry, Kakatiya University, Warangal 506 009, India

Received Date: 16 July 2007

Fund Project: The authors are grateful to The Director, Indian Institute of Chemical Technology, Hyderabad, for recording all NMR and mass spectra of the compounds published in this paper.

An efficient route for the synthesis of 5-(arylpropenylidine)-2, 4, 6-pyrimidinetrione 3 from an appropriate α, β-unsaturated aromatic aldehydes 1 and barbituric acid 2 under both non-catalytic and solvent-free microwave irradiation conditions was described. In this way, a range of biologically important compounds 3 was obtained in good to excellent yields (86-98%) in a very short reaction time (30-80 s).
- Barbituric acid,
- Knoevenagel condensation,
- 5-(Arylpropenylidine)-2,4,6-pyrimidinetrione
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