引用本文:
Yun Xu Yang, Hui Yuan Guo. Synthesis of 6,8-dichloroquinolones utilizing new method and evaluation of their antibacterial activities[J]. Chinese Chemical Letters,
2007, 18(12): 1479-1482.
doi:
10.1016/j.cclet.2007.10.012
Citation: Yun Xu Yang, Hui Yuan Guo. Synthesis of 6,8-dichloroquinolones utilizing new method and evaluation of their antibacterial activities[J]. Chinese Chemical Letters, 2007, 18(12): 1479-1482. doi: 10.1016/j.cclet.2007.10.012
Citation: Yun Xu Yang, Hui Yuan Guo. Synthesis of 6,8-dichloroquinolones utilizing new method and evaluation of their antibacterial activities[J]. Chinese Chemical Letters, 2007, 18(12): 1479-1482. doi: 10.1016/j.cclet.2007.10.012
Synthesis of 6,8-dichloroquinolones utilizing new method and evaluation of their antibacterial activities
摘要:
Several 6, 8-dichloroquinolone analogues were synthesized from the key intermediate compound of 2, 3, 4, 5-tetrachlorobenzene carbonyl chloride, which was obtained from the starting material of tetrachlorophthalic anhydride. Their in vitro antibacterial activities were evaluated. As a result of this study, compounds 21c and 21d were twofold more potent than ciprofloxacin (CPFX) and norfloxacin (NFLX) against Staphylococcus aureus-9, and with the same potent as CPFX and NFLX while against Escherichia coli-2, but were less potent than references in against Pseudomonas aeruginosa-17.
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关键词:
- Quinolones
- / Synthesis
- / Antibacterial
- / 6,8-Dichloroquinolone
English
Synthesis of 6,8-dichloroquinolones utilizing new method and evaluation of their antibacterial activities
Abstract:
Several 6, 8-dichloroquinolone analogues were synthesized from the key intermediate compound of 2, 3, 4, 5-tetrachlorobenzene carbonyl chloride, which was obtained from the starting material of tetrachlorophthalic anhydride. Their in vitro antibacterial activities were evaluated. As a result of this study, compounds 21c and 21d were twofold more potent than ciprofloxacin (CPFX) and norfloxacin (NFLX) against Staphylococcus aureus-9, and with the same potent as CPFX and NFLX while against Escherichia coli-2, but were less potent than references in against Pseudomonas aeruginosa-17.
-
Key words:
- Quinolones
- / Synthesis
- / Antibacterial
- / 6,8-Dichloroquinolone
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