引用本文:
Dong Hong Li, Jun Lin Diao, Ke Gui Yu, Cheng He Zhou. Synthesis and anticancer activities of porphyrin induced anticancer drugs[J]. Chinese Chemical Letters,
2007, 18(11): 1331-1334.
doi:
10.1016/j.cclet.2007.09.012
Citation: Dong Hong Li, Jun Lin Diao, Ke Gui Yu, Cheng He Zhou. Synthesis and anticancer activities of porphyrin induced anticancer drugs[J]. Chinese Chemical Letters, 2007, 18(11): 1331-1334. doi: 10.1016/j.cclet.2007.09.012
Citation: Dong Hong Li, Jun Lin Diao, Ke Gui Yu, Cheng He Zhou. Synthesis and anticancer activities of porphyrin induced anticancer drugs[J]. Chinese Chemical Letters, 2007, 18(11): 1331-1334. doi: 10.1016/j.cclet.2007.09.012
Synthesis and anticancer activities of porphyrin induced anticancer drugs
摘要:
In view of the property of porphyrin's accumulation selectively in tumor, the ftorafur was modified by binding a porphyrin block to improve its tumor targeting and reduce its side effects. These novel porphyrin derivatives and metal compounds were synthesized under mild conditions with satisfactory yield, and the constructions of all these new compounds were characterized by UV, IR, MS, 1H NMR spectra and elementary analysis. Their anticancer activities were evaluated by MTT assay; the results indicated that the anticancer activities of compounds 4a-c were twice as high as that of ftorafur.
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关键词:
- Porphyrin
- / Ftorafur
- / Synthesis
- / Anticancer activities
English
Synthesis and anticancer activities of porphyrin induced anticancer drugs
Abstract:
In view of the property of porphyrin's accumulation selectively in tumor, the ftorafur was modified by binding a porphyrin block to improve its tumor targeting and reduce its side effects. These novel porphyrin derivatives and metal compounds were synthesized under mild conditions with satisfactory yield, and the constructions of all these new compounds were characterized by UV, IR, MS, 1H NMR spectra and elementary analysis. Their anticancer activities were evaluated by MTT assay; the results indicated that the anticancer activities of compounds 4a-c were twice as high as that of ftorafur.
-
Key words:
- Porphyrin
- / Ftorafur
- / Synthesis
- / Anticancer activities
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